I'm open to pretty much all sorts of gaming though I do have mu favourites. Steampunk, pulp-action, sci-fi, urban fantasy and real-politk swords and sorcery all have special place inside my heart. Just something about playing out the logical consequences of magic/advanced technology on individuals and soceity as a whole makes my brain rush.
As far as settings go, Exalted, Dark Sun, Birthright, Dragonstar, Nova Praxis, Brave New World, L5R and Reign are my current big 8.